Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization.

ABSTRACT:

Background

Decidualization of endometrial cells is the prerequisite for embryo implantation and subsequent placenta formation and is induced by rising progesterone levels following ovulation. One of the hormone receptors contributing to endometrial homeostasis is Progesterone Receptor Membrane Component 1 (PGRMC1), a non-classical membrane-bound progesterone receptor with yet unclear function. In this study, we aimed to investigate how PGRMC1 contributes to human decidualization.

Methods

We first analyzed PGRMC1 expression profile during a regular menstrual cycle in RNA-sequencing datasets. To further explore the function of PGRMC1 in human decidualization, we implemented an inducible decidualization system, which is achieved by culturing two human endometrial stromal cell l

SUBMITTER: Liu H 

PROVIDER: S-EPMC10837943 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature