Early life exposure of infants to benzylpenicillin and gentamicin is associated with a persistent amplification of the gut resistome.

ABSTRACT:

Background

Infant gut microbiota is highly malleable, but the long-term longitudinal impact of antibiotic exposure in early life, together with the mode of delivery on infant gut microbiota and resistome, is not extensively studied.

Methods

Two hundred and eight samples from 45 infants collected from birth until 2 years of age over five time points (week 1, 4, 8, 24, year 2) were analysed. Based on shotgun metagenomics, the gut microbial composition and resistome profile were compared in the early life of infants divided into three groups: vaginal delivery/no-antibiotic in the first 4 days of life, C-section/no-antibiotic in the first 4 days of life, and C-section/antibiotic exposed in first 4 days of life. Gentamycin and benzylpenicillin were the most commonly administered

SUBMITTER: Patangia DV 

PROVIDER: S-EPMC10837951 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature