Biological basis of extensive pleiotropy between blood traits and cancer risk.

ABSTRACT:

Background

The immune system has a central role in preventing carcinogenesis. Alteration of systemic immune cell levels may increase cancer risk. However, the extent to which common genetic variation influences blood traits and cancer risk remains largely undetermined. Here, we identify pleiotropic variants and predict their underlying molecular and cellular alterations.

Methods

Multivariate Cox regression was used to evaluate associations between blood traits and cancer diagnosis in cases in the UK Biobank. Shared genetic variants were identified from the summary statistics of the genome-wide association studies of 27 blood traits and 27 cancer types and subtypes, applying the conditional/conjunctional false-discovery rate approach. Analysis of genomic positions, expression

SUBMITTER: Pardo-Cea MA 

PROVIDER: S-EPMC10837955 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature