The Impact of Opioid Receptor Gene Polymorphism on Fentanyl and Alfentanil's Analgesic Effects in the Pediatric Perioperative Period.

ABSTRACT:

Introduction

The polymorphism of the gene coding mu-opioid receptor (OPRM1) is one of the factors contributing to the variability in the response to opioid analgesics in children. The goal of this study is to investigate its role in association with postoperative acute pain in children of various ages.

Methods

This prospective study analyzed 110 pediatric patients, after plastic or orthopedic surgery, who were genotyped and randomly assigned to receive fentanyl or alfentanil. Postoperative pain was rated using Numerical Rating Scale (0-10). All the patients were genotyped forOPRM1 118A>G (rs1799971) gene polymorphism.

Results

School children under the age of 11 with the OPRM1 AA genotype were shown to have a higher BMI (p<0.05). Children ov

SUBMITTER: Lilic J 

PROVIDER: S-EPMC10838050 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature