Circulating cell-free DNA-based methylation pattern in plasma for early diagnosis of esophagus cancer.

ABSTRACT: With the increased awareness of early tumor detection, the importance of detecting and diagnosing esophageal cancer in its early stages has been underscored. Studies have consistently demonstrated the crucial role of methylation levels in circulating cell-free DNA (cfDNA) in identifying and diagnosing early-stage cancer. cfDNA methylation pertains to the methylation state within the genomic scope of cfDNA and is strongly associated with cancer development and progression. Several research teams have delved into the potential application of cfDNA methylation in identifying early-stage esophageal cancer and have achieved promising outcomes. Recent research supports the high sensitivity and specificity of cfDNA methylation in early esophageal cancer diagnosis, providing a more accurate and ef

SUBMITTER: Wang R 

PROVIDER: S-EPMC10838104 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature