Differences in methylation profiles between long-term survivors and short-term survivors of IDH-wild-type glioblastoma.

ABSTRACT:

Background

Patients with glioblastoma (GBM) have a median overall survival (OS) of approximately 16 months. However, approximately 5% of patients survive >5 years. This study examines the differences in methylation profiles between long-term survivors (>5 years, LTS) and short-term survivors (<1 year, STS) with isocitrate dehydrogenase (IDH)-wild-type GBMs.

Methods

In a multicenter retrospective analysis, we identified 25 LTS with a histologically confirmed GBM. They were age- and sex-matched to an STS. The methylation profiles of all 50 samples were analyzed with EPIC 850k, classified according to the DKFZ methylation classifier, and the methylation profiles of LTS versus STS were compared.

Results

After methylation profiling, 16/25 LTS and 23/25 STS were confirmed t

SUBMITTER: van der Meulen M 

PROVIDER: S-EPMC10838123 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature