Adult neuro-oncology trials in the United States over 5 decades: Analysis of trials completion rate to guide the path forward.

ABSTRACT:

Background

Clinical trials are important to close the gap between therapeutic unmet needs and scientific advances in neuro-oncology. This study analyzes the landscape of neuro-oncology trials to identify completion rates and guide strategies for the path forward.

Methods

US-registered adult neuro-oncology clinical trials were extracted from www.clinicaltrials.gov (1966-2019), including funding source, trial type, scope, phase, and subjects' demographics. Completed trials defined as those that had completed participants' examinations or intervention administration for the purpose of the final collection of data for the primary outcome were dichotomized against those that failed to reach completion. Univariate and multivariate analyses were used to detect differences across fa

SUBMITTER: Smith EJ 

PROVIDER: S-EPMC10838133 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature