The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency.

ABSTRACT: Deciphering the mechanisms underlying viral persistence is critical to achieving a cure for human immunodeficiency virus (HIV) infection. Here, we implement a systems approach to discover molecular signatures of HIV latently infected CD4⁺ T cells, identifying the immunosuppressive, adenosine-producing ectonucleotidase CD73 as a key surface marker of latent cells. Hypoxic conditioning, reflecting the lymphoid tissue microenvironment, increases the frequency of CD73⁺ CD4⁺ T cells and promotes HIV latency. Transcriptomic profiles of CD73⁺ CD4⁺ T cells favor viral quiescence, immune evasion, and cell survival. CD73⁺ CD4⁺ T cells are capable of harboring a functional HIV reservoir and reinitiating productive infection

SUBMITTER: Sperber HS 

PROVIDER: S-EPMC10838153 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature