Recombinant mannan-binding lectin magnetic beads increase pathogen detection in immunocompromised patients.

ABSTRACT: The microbiological diagnosis of infection for hematological malignancy patients receiving chemotherapy or allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients relies primarily on standard microbial culture, especially blood culture, which has many shortcomings, such as having low positive rates, being time-consuming and having a limited pathogenic spectrum. In this prospective observational self-controlled test accuracy study, blood, cerebrospinal fluid (CSF), and bronchoalveolar lavage fluid (BALF) samples were collected from chemotherapy or allo-HSCT patients with clinical symptoms of infections who were hospitalized at Peking University First Hospital. Possible pathogens were detected by the method based on recombinant mannan-binding lectin (MBL) magnetic bead enrich

SUBMITTER: Xiao-Ping C 

PROVIDER: S-EPMC10838228 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature