D-Amino acids differentially trigger an inflammatory environment in vitro.

ABSTRACT: Studies in vivo have demonstrated that the accumulation of D-amino acids (D-AAs) is associated with age-related diseases and increased immune activation. However, the underlying mechanism(s) of these observations are not well defined. The metabolism of D-AAs by D-amino oxidase (DAO) produces hydrogen peroxide (H₂O₂), a reactive oxygen species involved in several physiological processes including immune response, cell differentiation, and proliferation. Excessive levels of H₂O₂ contribute to oxidative stress and eventual cell death, a characteristic of age-related pathology. Here, we explored the molecular mechanisms of D-serine (D-Ser) and D-alanine (D-Ala) in human liver cancer cells, HepG2, with a focus on the production of H₂O₂

SUBMITTER: Yap SH 

PROVIDER: S-EPMC10838247 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature