Longitudinal changes in brain oxygen extraction fraction (OEF) in older adults: Relationship to markers of vascular and Alzheimer's pathology.

ABSTRACT:

Introduction

Oxygen extraction fraction (OEF) reflects the balance between oxygen delivery and consumption. We longitudinally measured OEF in older adults to examine the relationship with markers of Alzheimer's disease (AD) and vascular pathology.

Methods

One hundred thirty-seven participants were studied at two time-points at an interval of 2.16 years. OEF was measured using T₂ -relaxation-under-spin-tagging (TRUST) magnetic resonance imaging (MRI). The association between OEF and vascular risks, white matter hyperintensities (WMH), cerebrospinal fluid (CSF) measures of amyloid beta (Aβ), total tau (t-tau), and phosphorylated tau 181 (p-tau181) was examined.

Results

OEF increased from baseline to follow-up. The increase in OEF was more prominent in individ

SUBMITTER: Lin Z 

PROVIDER: S-EPMC10838398 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature