Single-cell transcriptome analysis reveals immunosuppressive landscape in overweight and obese colorectal cancer.

ABSTRACT:

Background

Overweight and obesity are established risk factors for various types of cancers including colorectal cancer (CRC). However the underlying molecular mechanisms remain unclear. An in-depth understanding of the oncologic characteristics of overweight and obese CRC at the single-cell level can provide valuable insights for the development of more effective treatment strategies for CRC.

Methods

We conducted single-cell RNA sequencing (scRNA-seq) analysis on tumor and adjacent normal colorectal samples from 15 overweight/obese and 15 normal-weight CRC patients. Immunological and metabolic differences between overweight/obese CRC and non-obese CRC were characterized.

Results

We obtained single-cell transcriptomics data from a total of 192,785 cells across all sam

SUBMITTER: Xiao G 

PROVIDER: S-EPMC10838453 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature