Does Walking Have an Association with Osteoarthritis? A Two-Sample Mendelian Randomization Analysis.

ABSTRACT:

Objective

Osteoarthritis (OA) is one of the major disabling human diseases. The related studies indicate a potential correlation between walking and OA. However, there is still a lack of evidence in genetics to support the correlation between walking and OA. Therefore, this study aimed to explore the relationship between walking and OA at the genetic level.

Methods

The publicly available Genome Wide Association Study (GWAS) data were used, with inverse variance weighting (IVW, the random-effects model) as the main analysis method, whereas MR-Egger, Weighted median, Simple mode, and Weighted mode as the secondary analysis methods. In addition, Cochran's Q test, pleiotropy test, and MR-Egger intercept test were conducted to examine the heterogeneity and pleiotropy of the outco

SUBMITTER: Xu J 

PROVIDER: S-EPMC10838505 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature