Trends, patterns, and maternal characteristics of opioid prescribing during pregnancy in a large population-based cohort study.

ABSTRACT:

Background

Opioid use during pregnancy has been associated with adverse maternal and infant health outcomes. Prescription drug monitoring programs (PDMP) provide a population-based source of prescription data. We linked statewide PDMP and birth certificate data in Tennessee (TN) to determine patterns of prescription opioid and benzodiazepine use during pregnancy.

Methods

We constructed a cohort of 311,217 live singleton births from 2013 to 2016 with prescription history from 90 days before pregnancy to birth. Descriptive statistics were used to describe opioid prescription patterns during pregnancy overall, by maternal characteristics and by year. Multivariable logistic regression models estimated adjusted odds ratios and 95% confidence intervals for factors associated with

SUBMITTER: Nechuta S 

PROVIDER: S-EPMC10838571 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature