Genetic and epigenetic determinants of non-alcoholic fatty liver disease (NAFLD) in lean individuals: a systematic review.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is common in obese individuals, but its occurrence in lean individuals and the underlying mechanisms are not well understood. This study aimed to systematically review the literature on the genetic and epigenetic factors influencing NAFLD in lean individuals.

Methods

A comprehensive search was conducted on April 2^nd, 2023, in seven databases using specific criteria. Only peer-reviewed studies in English, focusing on genetic or epigenetic effects on NAFLD in lean individuals, were included for qualitative synthesis. The Newcastle Ottawa Scale (NOS) was used for quality assessment. This study is registered with PROSPERO (CRD42023413809).

Results

Following PRISMA guidelines, 18 studies were included in this

SUBMITTER: Njei B 

PROVIDER: S-EPMC10838615 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature