Enteric glial cells contribute to chronic stress-induced alterations in the intestinal microbiota and barrier in rats.

ABSTRACT:

Background

Emerging evidence has demonstrated the impact of psychological stress on intestinal microbiota, however, the precise mechanisms are not fully understood. Enteric glia, a unique type of peripheral glia found within the enteric nervous system (ENS), play an active role in enteric neural circuits and have profound effects on gut functions. In the present study, we tested the hypothesis that enteric glia are involved in the alterations in the intestinal microflora and barrier induced by chronic water-avoidance stress (WAS) in the gut.

Methods and results

Western blotting and immunohistochemical (IHC) staining were used to examine the expression of glial fibrillary acidic protein (GFAP), nitric oxide synthetase (NOS) and choline acety1transferase (ChAT) in colon tissue

SUBMITTER: Lu T 

PROVIDER: S-EPMC10838753 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature