The Effects of Safinamide in Chinese and Non-Chinese Patients with Parkinson's Disease.

ABSTRACT:

Introduction

Ethnicity differences are an important determinant in the clinical manifestation of Parkinson's disease (PD), but they are not yet widely recognized, particularly regarding the response to dopaminergic medications. The aim of this paper is to analyze the efficacy and safety of safinamide in Chinese patients with PD in the pivotal studies SETTLE and XINDI compared to the non-Chinese population of the SETTLE trial.

Methods

SETTLE (NCT00627640) and XINDI (NCT03881371) were phase III, randomized, double-blind, placebo-controlled, multicenter trials. Patients received safinamide or placebo as add-on to levodopa. The primary efficacy endpoint was the change in the mean total daily OFF time. Secondary efficacy endpoints included total daily ON time, ON time with no/non

SUBMITTER: Cattaneo C 

PROVIDER: S-EPMC10838837 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature