Plasma and urine proteomics and gut microbiota analysis reveal potential factors affecting COVID-19 vaccination response.
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ABSTRACT:
SUBMITTER: Hu C
PROVIDER: S-EPMC10838952 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
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Plasma and urine proteomics and gut microbiota analysis reveal potential factors affecting COVID-19 vaccination response.
Hu Changjiang C Hu Weichao W Tang Bo B Bao Qiyu Q Jiang Xingyu X Tang Li L Wang He H He Lijiao L Lv Moyang M Xiao Yufeng Y Liu Cheng C Li Xinzhe X Liu Yunyi Y Li Jie J Huang Guiping G Dong Zhen Z Li Zhongjun Z Guo Tiannan T Yang Shiming S
iScience 20240108 2
The efficacy of COVID-19 vaccination relies on the induction of neutralizing antibodies, which can vary among vaccine recipients. In this study, we investigated the potential factors affecting the neutralizing antibody response by combining plasma and urine proteomics and gut microbiota analysis. We found that activation of the LXR/FXR pathway in plasma was associated with the production of ACE2-RBD-inhibiting antibodies, while urine proteins related to complement system, acute phase response si ...[more]
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