Immune evasion by proteolytic shedding of natural killer group 2, member D ligands in Helicobacter pylori infection.

ABSTRACT:

Background

Helicobacter pylori (H. pylori) uses various strategies that attenuate mucosal immunity to ensure its persistence in the stomach. We recently found evidence that H. pylori might modulate the natural killer group 2, member 2 (NKG2D) system. The NKG2D receptor and its ligands are a major activation system of natural killer and cytotoxic T cells, which are important for mucosal immunity and tumor immunosurveillance. The NKG2D system allows recognition and elimination of infected and transformed cells, however viruses and cancers often subvert its activation. Here we aimed to identify a potential evasion of the NKG2D system in H. pylori infection.

Methods

We analyzed expression of NKG2D system genes in gastric tissues of H. pylori ga

SUBMITTER: Anthofer M 

PROVIDER: S-EPMC10839011 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature