The pediatric gut bacteriome and virome in response to SARS-CoV-2 infection.

ABSTRACT:

Introduction

Since the beginning of the SARS-CoV-2 pandemic in early 2020, it has been apparent that children were partially protected from both infection and the more severe forms of the disease. Many different mechanisms have been proposed to explain this phenomenon, including children's frequent exposure to other upper respiratory infections and vaccines, and which inflammatory cytokines they are more likely to produce in response to infection. Furthermore, given the presence of SARS-CoV-2 in the intestine and its ability to infect enterocytes, combined with the well described immunomodulatory capabilities of the microbiome, another potential contributing factor may be the presence of certain protective microbial members of the gut microbiota (GM).

Methods

We performed sh

SUBMITTER: Piazzesi A 

PROVIDER: S-EPMC10839054 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature