Mononuclear cell composition and activation in blood and mucosal tissue of eosinophilic esophagitis.

ABSTRACT:

Introduction

Eosinophilic esophagitis (EoE) is a chronic, inflammatory, antigen-driven disease of the esophagus. Tissue EoE pathology has previously been extensively characterized by novel transcriptomics and proteomic platforms, however the majority of surface marker determination and screening has been performed in blood due to mucosal tissue size limitations. While eosinophils, CD4⁺ T cells, mast cells and natural killer (NK) T cells were previously investigated in the context of EoE, an accurate picture of the composition of peripheral blood mononuclear cells (PBMC) and their activation is missing.

Methods

In this study, we aimed to comprehensively analyze the composition of peripheral blood mononuclear cells and their activation using surface marker measureme

SUBMITTER: Gruden E 

PROVIDER: S-EPMC10839056 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature