Aging differentially alters the transcriptome and landscape of chromatin accessibility in the male and female mouse hippocampus.

ABSTRACT: Aging-related memory impairment and pathological memory disorders such as Alzheimer's disease differ between males and females, and yet little is known about how aging-related changes in the transcriptome and chromatin environment differ between sexes in the hippocampus. To investigate this question, we compared the chromatin accessibility landscape and gene expression/alternative splicing pattern of young adult and aged mouse hippocampus in both males and females using ATAC-seq and RNA-seq. We detected significant aging-dependent changes in the expression of genes involved in immune response and synaptic function and aging-dependent changes in the alternative splicing of myelin sheath genes. We found significant sex-bias in the expression and alternative splicing of hundreds of genes, inc

SUBMITTER: Achiro JM 

PROVIDER: S-EPMC10839115 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature