Genomic heterogeneity of multiple synchronous lung cancers in Chinese population.

ABSTRACT:

Introduction

It is clinically challenging to infer the phylogenetic relationship between different tumor lesions of patients with multiple synchronous lung cancers (MSLC), whether these lesions are the result of independently evolved tumor or intrapulmonary metastases.

Methods

We used the Illumina X10 platform to sequence 128 stage I lung cancer samples collected from 64 patients with MSLC. All samples were analyzed for mutation spectra and phylogenetic inference.

Results

We detected genetic aberrations within genes previously reported to be recurrently altered in lung adenocarcinoma including, EGFR, ERBB2, TP53, BRAF, and KRAS. Other putative driver mutations identified were enriched in RTK-RAS signaling, TP53 signaling, and cell cycle. Also, we found some interestin

SUBMITTER: Zhao L 

PROVIDER: S-EPMC10839131 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature