Algorithmic approach utilizing histology and immunohistochemistry for the current classification of diffuse glioma.

ABSTRACT:

Introduction

Diffuse glioma constitutes 28% of primary brain tumors. Until recently morphologic appearance was the only criterion for classifying these tumors. However, WHO 2016 incorporates molecular information in the primary diagnosis of gliomas such as Isocitrate dehydrogenase 1 (IDH1), Alpha thalassemia/mental retardation syndrome X inked (ATRX) as well as 1p/19q codeletion on FISH. In a resource-limited setup where FISH is not available, Alpha internexin (INA) has been suggested as a surrogate IHC marker.

Material and methods

Cross-sectional study conducted in the Department of Pathology for two years. Tissue blocks and clinical as well as radiological details were obtained from departmental archives. After assessing the morphologic details, routine IHC markers such as

SUBMITTER: Panambur CB 

PROVIDER: S-EPMC10839248 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature