The efficacy of extracted Tanshinone compounds for infantile hemangiomas of the skin: results from a pilot study.

ABSTRACT:

Background

Infantile hemangiomas (IHs) on skin are conventionally treated with beta blockers, pulsed dye laser (PDL), or surgery, either invasive or limited to clinical conditions. Our preclinical studies suggested that Tanshinone, extracted from Salvia miltiorrhiza (Tanshin), had a beneficial effect on IHs. Thus, we conducted a pilot clinical study to evaluate the safety and efficacy of topical Tanshinone compounds on superficial IHs.

Methods

The single-armed pilot study included a total of 29 infants diagnosed with IHs. Thrice daily (at an interval of 6-8 hours) topical applications of Tanshinone were used for each patient. The primary response was the skin erythema index assessed by investigators using SkinColorCatch colorimeter instrument (Delfin). The Achauer sco

SUBMITTER: Huang Y 

PROVIDER: S-EPMC10839283 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature