Altered gut microbiome drives heightened pain sensitivity in a murine model of metastatic triple-negative breast cancer.

ABSTRACT: The microbiota residing in the gut environment is essential for host homeostasis. Increasing evidence suggests that microbial perturbation (dysbiosis) regulates cancer initiation and progression at local and distant sites. Here, we have identified microbial dysbiosis with the depletion of commensal bacteria as a host-intrinsic factor associated with metastatic dissemination to the bone. Using a mouse model of triple-negative mammary cancer, we demonstrate that a pre-established disruption of microbial homeostasis using an antibiotic cocktail increases tumor growth, enhanced circulating tumor cells, and subsequent dissemination to the bone. We found that the presence of pathogenic bacteria and loss of commensal bacteria in an antibiotic-induced gut environment is associated with sustained i

SUBMITTER: Dutta RK 

PROVIDER: S-EPMC10839306 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature