EEG-based spatiotemporal dynamics of fast ripple networks and hubs in infantile epileptic spasms.

ABSTRACT:

Objective

Infantile epileptic spasms (IS) are epileptic seizures that are associated with increased risk for developmental impairments, adult epilepsies, and mortality. Here, we investigated coherence-based network dynamics in scalp EEG of infants with IS to identify frequency-dependent networks associated with spasms. We hypothesized that there is a network of increased fast ripple connectivity during the electrographic onset of clinical spasms, which is distinct from controls.

Methods

We retrospectively analyzed peri-ictal and interictal EEG recordings of 14 IS patients. The data was compared with 9 age-matched controls. Wavelet phase coherence (WPC) was computed between 0.2 and 400 Hz. Frequency- and time-dependent brain networks were constructed using this coherence as t

SUBMITTER: Samfira IMA 

PROVIDER: S-EPMC10839371 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature