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Metal-free synthesis of γ-ketosulfones through Bronsted acid-promoted conjugate addition of sulfinamides.

ABSTRACT: A straightforward and general metal-free method has been developed to add sufinamide-derived sulfone units on Michael acceptors under mild conditions. This reaction enables the preparation of a large variety of original γ-ketosulfones, of which only a few synthetic methods have been reported. The mild reaction conditions used tolerate a wide diversity of functional groups and empower the implementation of a late-stage functionalisation strategy.

SUBMITTER: Gigant N

PROVIDER: S-EPMC10839551 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Metal-free synthesis of γ-ketosulfones through Brønsted acid-promoted conjugate addition of sulfinamides.

Gigant Nicolas N Kayal Sami S Drège Emmanuelle E Joseph Delphine D

RSC advances 20240101 7

A straightforward and general metal-free method has been developed to add sufinamide-derived sulfone units on Michael acceptors under mild conditions. This reaction enables the preparation of a large variety of original γ-ketosulfones, of which only a few synthetic methods have been reported. The mild reaction conditions used tolerate a wide diversity of functional groups and empower the implementation of a late-stage functionalisation strategy. ...[more]

PMID: 38318627

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