Dataset Information

Unraveling the role of serum metabolites in the relationship between plant-based diets and bone health in community-dwelling older adults.

ABSTRACT: The potential adverse effects of the plant-based dietary pattern on bone health have received widespread attention. However, the biological mechanisms underlying the adverse effects of plant-based diets on bone health remain incompletely understood. The objective of this study was to identify potential biomarkers between plant-based diets and bone loss utilizing metabolomic techniques in the Taizhou Imaging Study (TIS) (N = 788). Plant-based diet indexes (overall plant-based diet index (PDI), healthy plant-based diet index (hPDI), and unhealthy plant-based diet index (uPDI)) were calculated using the food frequency questionnaire, and bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry. A multinomial logistic regression was used to explore the associations of plant-based diet indexes with bone loss. Furthermore, mediation analysis and exploratory factor analysis (EFA) were performed to explore the mediated effects of metabolites on the association of plant-based diets with BMD T-score. Our results showed that higher hPDI and uPDI were positively associated with bone loss. Moreover, nineteen metabolites were significantly associated with BMD T-score, among them, seven metabolites were associated with uPDI. Except for cholesterol esters in VLDL-1, the remaining six metabolites significantly mediated the negative association between uPDI and BMD T-score. Interestingly, we observed that the same six metabolites mediated the positive association between fresh fruit and BMD T-score. Collectively, our results support the deleterious effects of plant-based diets on bone health and discover the potential mediation effect of metabolites on the association of plant-based diets with bone loss. The findings offer valuable insights that could optimize dietary recommendations and interventions, contributing to alleviate the potential adverse effects associated with plant-based diets.

SUBMITTER: Zheng Y

PROVIDER: S-EPMC10839558 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Unraveling the role of serum metabolites in the relationship between plant-based diets and bone health in community-dwelling older adults.

Zheng Yi Y Gao Ningxin N Li Yucan Y Fan Min M Tian Weizhong W Jiang Yanfeng Y Wang Yingzhe Y Cui Mei M Suo Chen C Zhang Tiejun T Jin Li L Xu Kelin K Chen Xingdong X

Current research in food science 20240123

The potential adverse effects of the plant-based dietary pattern on bone health have received widespread attention. However, the biological mechanisms underlying the adverse effects of plant-based diets on bone health remain incompletely understood. The objective of this study was to identify potential biomarkers between plant-based diets and bone loss utilizing metabolomic techniques in the Taizhou Imaging Study (TIS) (N = 788). Plant-based diet indexes (overall plant-based diet index (PDI), he ...[more]

PMID: 38318314

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Dataset Information

Unraveling the role of serum metabolites in the relationship between plant-based diets and bone health in community-dwelling older adults.

Publications

Unraveling the role of serum metabolites in the relationship between plant-based diets and bone health in community-dwelling older adults.

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