G protein-coupled receptor 30 activation inhibits ferroptosis and protects chondrocytes against osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA) is the most common joint disease worldwide, but its cause remains unclear. Oestrogen protects against OA, but its clinical use is limited. G protein-coupled receptor 30 (GPR30) is a receptor that binds oestrogen, and GPR30 treatment has benefitted patients with some degenerative diseases. However, its effects on OA prevention and treatment remain unclear. Moreover, several studies have found that activation of estrogen receptors exerting anti-ferroptosis effects, which plays an important role in chondrocyte survival. Therefore, this study explored the general and ferroptosis-related effects and mechanisms of GPR30 in OA.

Methods

Genome-wide RNA sequencing, western blotting, and immunohistochemistry were used to evaluate GPR30 expression and fer

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC10839561 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature