The Location of Biofilms on Chronic Prosthetic Joint Infections and the Ramifications for Clinical Practice.

ABSTRACT: Revision surgery is paramount to cure chronic prosthetic joint infections because these infections are associated with biofilms on prosthetics that conventional antibiotics cannot eradicate. However, there is a paucity of research on where in vivo biofilms are located on infected prosthetics. Consequently, the objective of this pilot study was to address this gap in knowledge by staining 5 chronically infected prosthetics, that were removed at the time of revision surgery, with methylene blue. Scanning electron microscopic images were then taken of the methylene blue-stained areas to visualize biofilms. The findings show that all chronically infected prosthetics had biofilms located on the bone-prosthetic interface, yet only 2 had biofilms also located on the prosthetic interface exposed t

SUBMITTER: Doub JB 

PROVIDER: S-EPMC10839572 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature