Early radiologic and metabolic tumour response assessment during combined chemo-radiotherapy for locally advanced NSCLC.

ABSTRACT:

Background

The role of early treatment response for patients with locally advanced non-small cell lung cancer (LA-NSCLC) treated with concurrent chemo-radiotherapy (cCRT) is unclear. The study aims to investigate the predictive value of response to induction chemotherapy (iCX) and the correlation with pattern of failure (PoF).

Materials and methods

Patients with LA-NSCLC treated with cCRT were included for analyses (n = 276). Target delineations were registered from radiotherapy planning PET/CT to diagnostic PET/CT, in between which patients received iCX. Volume, sphericity, and SUVpeak were extracted from each scan. First site of failure was categorised as loco-regional (LR), distant (DM), or simultaneous LR+M (LR+M). Fine and Gray models for PoF were performed: a baseline

SUBMITTER: Tvilum M 

PROVIDER: S-EPMC10839576 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature