Immune landscape of hepatocellular carcinoma tumor microenvironment identifies a prognostic relevant model.

ABSTRACT:

Background

Various studies highlighted that immune cell-mediated inflammatory processes play crucial roles in the progression and treatment of hepatocellular carcinoma (HCC). However, the immune microenvironment of HCC is still poorly characterized. Exploring the role of immune-related genes (IRGs) and describing the immune landscape in HCC would provide insights into tumor-immune co-evolution along HCC progression.

Methods

We integrated the datasets with complete prognostic information from the Cancer Genome Atlas (TCGA) database and GEO DataSets (GSE14520, GSE76427, and GSE54236) to construct a novel immune landscape based on the Cibersort algorithm and reveal the prognostic signature in HCC patients.

Results

To describe the tumor microenvironment (TME) in HCC, immu

SUBMITTER: Cao H 

PROVIDER: S-EPMC10839619 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature