NDRG1 is a prognostic biomarker in breast cancer and breast cancer brain metastasis.

ABSTRACT: Brain metastases are secondary brain tumours characterised by their aggressive nature and poor prognosis. Breast cancer is one of the most common primary tumours in women to spread to the brain. A lack of biomarkers predicting likely spread to the brain and limited therapeutic interventions represents major areas of clinical unmet need. We investigated N-myc downregulated gene-1 (NDRG1) as a clinically relevant biomarker in breast cancer brain metastasis patients. NDRG1 expression was investigated using immunohistochemistry on tissue microarrays of two clinical cohorts: (i) brain metastatic breast cancers (n = 48) and brain metastases (n = 64; including a subset of 39 patient-matched breast and brain metastasis cases) and (ii) unselected primary breast cancers (n = 336). NDRG1 was highly e

SUBMITTER: Joshi V 

PROVIDER: S-EPMC10839626 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature