Characterization of metabolic alterations in the lean metabolically unhealthy alpha defensin transgenic mice.

ABSTRACT: Inflammation is consistently linked to dysmetabolism. In transgenic mice (Def^+/+) model the neutrophilic peptide, alpha defensin, proved atherogenic. This phenotype occurred despite favorable cholesterol and glucose levels, and lower body weight and blood pressure. In this study, integration of metabolic&behavioral phenotyping system, endocrine, biochemical and mitochondrial assessment, pathological and immunohistochemical tests, and multiple challenge tests was established to explore the metabolic impact of alpha defensin. Compared to the control group, Def^+/+ mice exhibited lower total energy expenditure and carbohydrate utilization, and higher fat oxidation. Their ACTH-cortisol and thyroid profiles were intact. Intriguingly, they had low levels of glucagon, with hi

SUBMITTER: Higazi AA 

PROVIDER: S-EPMC10839648 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature