Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome.

ABSTRACT: Adipose tissue is the site of long-term energy storage. During the fasting state, exercise, and cold exposure, the white adipose tissue mobilizes energy for peripheral tissues through lipolysis. The mobilization of lipids from white adipose tissue to the liver can lead to excess triglyceride accumulation and fatty liver disease. Although the white adipose tissue is known to release free fatty acids, a comprehensive analysis of lipids mobilized from white adipocytes in vivo has not been completed. In these studies, we provide a comprehensive quantitative analysis of the adipocyte-secreted lipidome and show that there is interorgan crosstalk with liver. Our analysis identifies multiple lipid classes released by adipocytes in response to activation of lipolysis. Time-dependent analysis of the

SUBMITTER: Zhang S 

PROVIDER: S-EPMC10839691 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature