Disrupted pattern of rich-club organization in structural brain network from prediabetes to diabetes: A population-based study.

ABSTRACT: The network nature of the brain is gradually becoming a consensus in the neuroscience field. A set of highly connected regions in the brain network called "rich-club" are crucial high efficiency communication hubs in the brain. The abnormal rich-club organization can reflect underlying abnormal brain function and metabolism, which receives increasing attention. Diabetes is one of the risk factors for neurological diseases, and most individuals with prediabetes will develop overt diabetes within their lifetime. However, the gradual impact of hyperglycemia on brain structures, including rich-club organization, remains unclear. We hypothesized that the brain follows a special disrupted pattern of rich-club organization in prediabetes and diabetes. We used cross-sectional baseline data from th

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC10839741 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature