The immunological landscape of peripheral blood in glioblastoma patients and immunological consequences of age and dexamethasone treatment.

ABSTRACT:

Background

Glioblastomas manipulate the immune system both locally and systemically, yet, glioblastoma-associated changes in peripheral blood immune composition are poorly studied. Age and dexamethasone administration in glioblastoma patients have been hypothesized to limit the effectiveness of immunotherapy, but their effects remain unclear. We compared peripheral blood immune composition in patients with different types of brain tumor to determine the influence of age, dexamethasone treatment, and tumor volume.

Methods

High-dimensional mass cytometry was used to characterise peripheral blood mononuclear cells of 169 patients with glioblastoma, lower grade astrocytoma, metastases and meningioma. We used blood from medically-refractory epilepsy patients and healthy controls

SUBMITTER: Dusoswa SA 

PROVIDER: S-EPMC10839779 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature