Psoriasis and risk of central neurological disorders in European populations: A mendelian randomization analysis.

ABSTRACT:

Background

People with psoriasis are at a higher risk for having central neurological problems, according to previous studies; however, it is unclear if there is a genetic link between the risk of developing psoriasis and developing central neurological disorders. In this study, the possible link between genetically predisposed psoriasis and the risk of common central nervous system disorders was comprehensively investigated.

Methods

There was no overlap in the participant populations between the psoriasis and central neurological disorders genome-wide association studies, which provide the genetic resources. Inverse variance weighting, often used as Mendelian randomization (MR) analysis, is the main method. To guarantee the accuracy of our findings, a number of sensitivity

SUBMITTER: Li Y 

PROVIDER: S-EPMC10839951 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature