Ontology highlight
ABSTRACT:
SUBMITTER: Zhang SM
PROVIDER: S-EPMC10839966 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Zhang Si Min SM Paulin Cynthia B J CBJ Shu Huazhang H Yagüe-Capilla Miriam M Michel Maurice M Marttila Petra P Ortis Florian F Bwanika Henri Colyn HC Dirks Christopher C Venkatram Rajagopal Papagudi RP Wiita Elisée E Jemth Ann-Sofie AS Almlöf Ingrid I Loseva Olga O Hormann Femke M FM Koolmeister Tobias T Linde Erika E Lee Sun S Llona-Minguez Sabin S Haraldsson Martin M Axelsson Hanna H Strömberg Kia K Homan Evert J EJ Scobie Martin M Lundbäck Thomas T Helleday Thomas T Rudd Sean G SG
iScience 20240113 2
SAMHD1 is a dNTP triphosphohydrolase governing nucleotide pool homeostasis and can detoxify chemotherapy metabolites controlling their clinical responses. To understand SAMHD1 biology and investigate the potential of targeting SAMHD1 as neoadjuvant to current chemotherapies, we set out to discover selective small-molecule inhibitors. Here, we report a discovery pipeline encompassing a biochemical screening campaign and a set of complementary biochemical, biophysical, and cell-based readouts for ...[more]