Erzhi pills reverse PD-L1-mediated immunosuppression in melanoma microenvironment.

ABSTRACT:

Background

Cancer immunotherapies aimed at activating immune system, especially by blocking immune checkpoints, have become a successful modality for treating patients with advanced cancers. However, its clinical practice is frequently conceded by high outcomes, low initial response rates and severe side effects. New strategies are necessary to complement and advance this biological therapy. Erzhi Pills (EZP) have diverse pharmaceutical effects including immune regulation, anti-tumor and anti-senescence. We hypothesized that EZP could exert its antitumor effect through immunomodulation.

Purpose

The aim of this study was to investigate the effects of EZP on anti-tumor activities, and define its molecular mechanisms.

Methods

By applying melanoma model with high immune i

SUBMITTER: Fang Z 

PROVIDER: S-EPMC10839997 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature