Pro-inflammatory feedback loops define immune responses to pathogenic Lentivirus infection.

ABSTRACT:

Background

The Lentivirus human immunodeficiency virus (HIV) causes chronic inflammation and AIDS in humans, with variable rates of disease progression between individuals driven by both host and viral factors. Similarly, simian lentiviruses vary in their pathogenicity based on characteristics of both the host species and the virus strain, yet the immune underpinnings that drive differential Lentivirus pathogenicity remain incompletely understood.

Methods

We profile immune responses in a unique model of differential lentiviral pathogenicity where pig-tailed macaques are infected with highly genetically similar variants of SIV that differ in virulence. We apply longitudinal single-cell transcriptomics to this cohort, along with single-cell resolution cell-cell communication t

SUBMITTER: Wilk AJ 

PROVIDER: S-EPMC10840164 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature