Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans.

ABSTRACT:

Background

African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations is obscure. The Stroke Investigative Research and Educational Network (SIREN) is a multicenter study involving 16 sites in West Africa. We conducted the first-ever genome-wide association study (GWAS) of stroke in indigenous Africans.

Methods

Cases were consecutively recruited consenting adults (aged > 18 years) with neuroimaging-confirmed ischemic stroke. Stroke-free controls were ascertained using a locally validated Questionnaire for Verifying Stroke-Free Status. DNA genotyping with the H3Africa array was performed, and following initial quality control, GWAS datasets were imputed into the NIH Trans-Omics for Precision Medicine (TOPMed)

SUBMITTER: Akinyemi RO 

PROVIDER: S-EPMC10840175 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature