The impact of selective HDAC inhibitors on the transcriptome of early mouse embryos.

ABSTRACT:

Background

Histone acetylation, which is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), plays a crucial role in the control of gene expression. HDAC inhibitors (HDACi) have shown potential in cancer therapy; however, the specific roles of HDACs in early embryos remain unclear. Moreover, although some pan-HDACi have been used to maintain cellular undifferentiated states in early embryos, the specific mechanisms underlying their effects remain unknown. Thus, there remains a significant knowledge gap regarding the application of selective HDACi in early embryos.

Results

To address this gap, we treated early embryos with two selective HDACi (MGCD0103 and T247). Subsequently, we collected and analyzed their transcriptome data at different develop

SUBMITTER: Shao R 

PROVIDER: S-EPMC10840191 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature