LINC01559 promotes lung adenocarcinoma metastasis by disrupting the ubiquitination of vimentin.

ABSTRACT:

Background

Distant metastasis is the major cause of lung adenocarcinoma (LUAD)-associated mortality. However, molecular mechanisms involved in LUAD metastasis remain to be fully understood. While the role of long non-coding RNAs (lncRNAs) in cancer development, progression, and treatment resistance is being increasingly appreciated, the list of dysregulated lncRNAs that contribute to LUAD pathogenesis is also rapidly expanding.

Methods

Bioinformatics analysis was conducted to interrogate publicly available LUAD datasets. In situ hybridization and qRT-PCR assays were used to test lncRNA expression in human LUAD tissues and cell lines, respectively. Wound healing as well as transwell migration and invasion assays were employed to examine LUAD cell migration and invasion in vit

SUBMITTER: Feng H 

PROVIDER: S-EPMC10840222 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature