Th1 cells contribute to retinal ganglion cell loss in glaucoma in a VCAM-1-dependent manner.

ABSTRACT: Glaucoma is a complex neurodegenerative disorder characterized by the progressive loss of retinal ganglion cells (RGC) and optic nerve axons, leading to irreversible visual impairment. Despite its clinical significance, the underlying mechanisms of glaucoma pathogenesis remain poorly understood. In this study, we aimed to unravel the multifaceted nature of glaucoma by investigating the interaction between T cells and retinas. By utilizing clinical samples, murine glaucoma models, and T cell transfer models, we made several key findings. Firstly, we observed that CD4⁺ T cells from glaucoma patients displayed enhanced activation and a bias towards T helper (Th) 1 responses, which correlated with visual impairment. Secondly, we identified the infiltration of Th1 cells into the reti

SUBMITTER: He C 

PROVIDER: S-EPMC10840227 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature