Associations between ADHD and risk of six psychiatric disorders: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies and diagnostic criteria have indicated that Attention Deficit Hyperactivity Disorder (ADHD) frequently comorbid with various psychiatric disorders. Therefore, we conducted a Mendelian randomization (MR) study to explore this potential genetic association between ADHD and six psychiatric disorders.

Methods

Using a two-sample Mendelian randomization (MR) design, this study systematically screened genetic instrumental variables (IVs) based on the genome-wide association studies (GWAS) of ADHD and six psychiatric disorders, with the inverse variance weighted (IVW) method as the primary approach.

Results

The study revealed a positive and causal association between ADHD and the risk of ASD, with an odds ratio (OR) of 2.328 (95%CI: 1.241-4.36

SUBMITTER: Guo Y 

PROVIDER: S-EPMC10840247 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature