Gut microbiota-derived LCA mediates the protective effect of PEDV infection in piglets.

ABSTRACT:

Background

The gut microbiota is a critical factor in the regulation of host health, but the relationship between the differential resistance of hosts to pathogens and the interaction of gut microbes is not yet clear. Herein, we investigated the potential correlation between the gut microbiota of piglets and their disease resistance using single-cell transcriptomics, 16S amplicon sequencing, metagenomics, and untargeted metabolomics.

Results

Porcine epidemic diarrhea virus (PEDV) infection leads to significant changes in the gut microbiota of piglets. Notably, Landrace pigs lose their resistance quickly after being infected with PEDV, but transplanting the fecal microbiota of Min pigs to Landrace pigs alleviated the infection status. Macrogenomic and animal protection models

SUBMITTER: Xing JH 

PROVIDER: S-EPMC10840300 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature