Identification of HSPD1 as a novel invasive biomarker associated with mitophagy in pituitary adenomas.

ABSTRACT:

Background

The crucial role of mitophagy in tumor progression has been recognized. Therefore, our study aimed to investigate the potential correlation between pituitary adenoma invasiveness and the mitophagy processes.

Methods

In this study, we used transcriptomics of postoperative tissue from 32 patients and quantitative proteomics of 19 patients to screen for mitophagy-related invasion genes in pituitary adenomas. The invasive predictive value of target genes was analyzed by Lasso regression model, CytoHubba plugin and expression validation. Co-expression correlation analysis was used to identify paired proteins for target genes, and a predictive model for pituitary adenoma invasiveness was constructed by target genes and paired proteins and assessed using ROC analysis, ca

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10840335 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature