Insights into the influence of three types of sugar on goose fatty liver formation from endoplasmic reticulum stress (ERS).

ABSTRACT: This study analyzed the formation of goose fatty liver due to endoplasmic reticulum stress (ERS) caused by 3 types of sugar. Transcriptome analysis was performed for liver tissues from geese fed a traditional diet (maize flour), geese overfed with traditional diet, and geese overfed with diet supplemented with glucose, fructose, or sucrose. Correlation analysis of the liver tissue transcriptomes showed that differentially expressed genes (DEGs) involved in ERS were significantly negatively correlated with DEGs involved in inflammation response in the sucrose overfeeding group, and significantly positively correlated with the DEGs involved in lipid metabolism in fructose overfeeding group. Goose primary hepatocytes were isolated in vitro and then treated with glucose or fructose. Some were

SUBMITTER: Wei R 

PROVIDER: S-EPMC10840336 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature